Assay Detail
Binding
CHEMBL3807011
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Fluormone ES2 from human recombinant full length untagged-ERalpha by fluorescence polarization competition binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.97 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 9.33 |
| CHEMBL3805385 | — | — | 1 | 8.74 |
| CHEMBL3805318 | — | — | 1 | 8.23 |
| CHEMBL3805025 | — | — | 1 | 7.96 |
| CHEMBL3804907 | — | — | 1 | 7.55 |
| CHEMBL3806167 | — | — | 1 | 7.40 |
| CHEMBL3805170 | — | — | 1 | 7.31 |
| CHEMBL3805921 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81 | RALOXIFENE | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL3805385 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3805318 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3805025 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3804907 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3806167 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3805170 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3805921 | — | IC50 | = | 61.0 | nM | 7.21 |