Assay Detail
Binding
CHEMBL3807233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged TNKS1 (1023 to 1327 residues) (unknown origin) autoparsylation using biotinylated NAD incubated for 1 hr by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Poly [ADP-ribose] polymerase tankyrase-1 (CHEMBL6164) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential Use of Inhibitors of Tankyrases and PARP-1 as Treatment for Cancer and Other Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.27 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3805896 | — | — | 1 | 9.74 |
| CHEMBL3806163 | — | — | 1 | 9.70 |
| CHEMBL3805393 | — | — | 1 | 9.62 |
| CHEMBL3804939 | — | — | 1 | 9.40 |
| CHEMBL3806049 | — | — | 1 | 9.09 |
| CHEMBL3805627 | — | — | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3805896 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL3806163 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3805393 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL3804939 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3806049 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL3805627 | — | IC50 | = | 8.5 | nM | 8.07 |