Assay Detail
Binding
CHEMBL3810635
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Inhibition of NFkappaB transcription in human SW480 cells at by luciferase reporter gene assay
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.74 | 5.29 |
| Inhibition | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611368 | LICOCOUMARONE | — | 2 | 5.29 |
| CHEMBL3808856 | — | — | 2 | 4.77 |
| CHEMBL480477 | GLABRIDIN | — | 2 | 4.67 |
| CHEMBL3810076 | — | — | 2 | 4.61 |
| CHEMBL3809110 | — | — | 2 | 4.59 |
| CHEMBL64925 | MG-132 | — | 2 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611368 | LICOCOUMARONE | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3808856 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL480477 | GLABRIDIN | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL3810076 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL3809110 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL64925 | MG-132 | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL3810076 | — | Inhibition | - | % | - | |
| CHEMBL3808856 | — | Inhibition | - | % | - | |
| CHEMBL611368 | LICOCOUMARONE | Inhibition | - | % | - | |
| CHEMBL3809110 | — | Inhibition | - | % | - | |
| CHEMBL480477 | GLABRIDIN | Inhibition | - | % | - | |
| CHEMBL64925 | MG-132 | Inhibition | - | % | - |