Assay Detail
Binding
CHEMBL3811320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AXL (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.60 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 7.96 |
| CHEMBL3809908 | — | — | 1 | 7.24 |
| CHEMBL3301622 | GILTERITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3809908 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3301622 | GILTERITINIB | IC50 | < | 1.0 | nM | - |