Assay Detail
Binding
CHEMBL3811607
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Inhibition of hedgehog pathway in mouse ASZ cells assessed as downregulation of Gli1 mRNA expression after 48 hrs by qPCR method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | ASZ |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.63 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3808414 | — | — | 1 | 7.66 |
| CHEMBL3809416 | — | — | 1 | 7.62 |
| CHEMBL3809814 | — | — | 1 | 7.15 |
| CHEMBL3809819 | — | — | 1 | 7.11 |
| CHEMBL3809592 | — | — | 1 | 7.05 |
| CHEMBL3809342 | — | — | 1 | 6.92 |
| CHEMBL3810392 | — | — | 1 | 6.92 |
| CHEMBL3809889 | — | — | 1 | 6.89 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 6.85 |
| CHEMBL3810051 | — | — | 1 | 6.85 |
| CHEMBL3808841 | — | — | 1 | 6.82 |
| CHEMBL3808643 | — | — | 1 | 6.80 |
| CHEMBL3809786 | — | — | 1 | 6.77 |
| CHEMBL3808738 | — | — | 1 | 6.70 |
| CHEMBL3808913 | — | — | 1 | 6.42 |
| CHEMBL3810370 | — | — | 1 | 6.35 |
| CHEMBL3808561 | — | — | 1 | 6.27 |
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 6.27 |
| CHEMBL3808890 | — | — | 1 | 6.26 |
| CHEMBL3809358 | — | — | 1 | 5.89 |
| CHEMBL3810069 | — | — | 1 | 5.85 |
| CHEMBL3809392 | — | — | 1 | 5.60 |
| CHEMBL3809423 | — | — | 1 | 5.55 |
| CHEMBL1310553 | — | — | 1 | - |
| CHEMBL3810381 | — | — | 1 | - |
| CHEMBL3808651 | — | — | 1 | - |
| CHEMBL3809455 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3808414 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3809416 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3809814 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3809819 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3809592 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3809342 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3810392 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3809889 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3810051 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3808841 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3808643 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3809786 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3808738 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3808913 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3810370 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3808561 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1397 | POSACONAZOLE | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3808890 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3809358 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3810069 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3809392 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3809423 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1310553 | — | IC50 | - | — | - | |
| CHEMBL3810381 | — | IC50 | - | — | - | |
| CHEMBL3808651 | — | IC50 | - | — | - | |
| CHEMBL3809455 | — | IC50 | - | — | - |