Assay Detail
Binding
CHEMBL3811611
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hedgehog pathway in mouse MERP MB cells assessed as downregulation of Gli1 mRNA expression after 48 hrs by qPCR method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.56 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3808414 | — | — | 1 | 6.72 |
| CHEMBL3808841 | — | — | 1 | 6.58 |
| CHEMBL3809416 | — | — | 1 | 6.54 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3808414 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3808841 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3809416 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 390.0 | nM | 6.41 |