Assay Detail
Binding
CHEMBL3812667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Time-dependent inhibition of wild type Klebsiella pneumoniae 6xHis-tagged metallo-beta-lactamase NDM-1 expressed in Escherichia coli BL21 (DE3)pLysS
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Klebsiella pneumoniae |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metallo-beta-lactamase type 2 (CHEMBL1667695) ↗| Type | SINGLE PROTEIN |
| Organism | Klebsiella pneumoniae |
Publication
Discovery of a novel covalent non-β-lactam inhibitor of the metallo-β-lactamase NDM-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 6.24 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86905 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86905 | — | Ki | = | 580.0 | nM | 6.24 |