Assay Detail
Functional
CHEMBL3813044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by WST-8 reduction assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.75 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3808922 | — | — | 1 | 5.25 |
| CHEMBL3808412 | — | — | 1 | 4.92 |
| CHEMBL3809952 | — | — | 1 | 4.85 |
| CHEMBL3809815 | — | — | 1 | 4.68 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | — | 1 | 4.66 |
| CHEMBL3810128 | — | — | 1 | 4.50 |
| CHEMBL430464 | MESODIHYDROGUAIARETIC ACID | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3808922 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3808412 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3809952 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3809815 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3810128 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL430464 | MESODIHYDROGUAIARETIC ACID | IC50 | = | 41000.0 | nM | 4.39 |