Assay Detail
Binding
CHEMBL3813261
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Inhibition of Escherichia coli GroEL/GroES using Escherichia coli GroEL expressed in Escherichia coli DH5alpha cells and Escherichia coli GroES expressed in Escherichia coli BL21(DE3) cells assessed as reduction in native refolded rhodanese-mediated thiocyanate production by micro plate reader analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
GroEL/ES inhibitors as potential antibiotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.23 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3115913 | — | — | 1 | 6.60 |
| CHEMBL1411862 | — | — | 1 | 5.85 |
| CHEMBL1557710 | — | — | 1 | 5.68 |
| CHEMBL1713063 | — | — | 1 | 5.60 |
| CHEMBL3115927 | — | — | 1 | 5.28 |
| CHEMBL3115920 | — | — | 1 | 5.09 |
| CHEMBL3116086 | — | — | 1 | 5.00 |
| CHEMBL3115926 | — | — | 1 | 4.92 |
| CHEMBL3115914 | — | — | 1 | 4.92 |
| CHEMBL3115911 | — | — | 1 | 4.85 |
| CHEMBL3112623 | — | — | 1 | 4.64 |
| CHEMBL3115929 | — | — | 1 | 4.28 |
| CHEMBL3115921 | — | — | 1 | - |
| CHEMBL3115919 | — | — | 1 | - |
| CHEMBL3115924 | — | — | 1 | - |
| CHEMBL3115912 | — | — | 1 | - |
| CHEMBL1632145 | — | — | 1 | - |
| CHEMBL3115928 | — | — | 1 | - |
| CHEMBL3115908 | — | — | 1 | - |
| CHEMBL3116087 | — | — | 1 | - |
| CHEMBL3116088 | — | — | 1 | - |
| CHEMBL3116089 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3115913 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1411862 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1557710 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1713063 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3115927 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3115920 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3116086 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3115926 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3115914 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3115911 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3112623 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3115929 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL3115921 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115919 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115924 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115912 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1632145 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115928 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115908 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3116087 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3116088 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3116089 | — | IC50 | > | 100000.0 | nM | - |