Assay Detail
Binding
CHEMBL3813263
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Inhibition of Escherichia coli GroEL/GroES using Escherichia coli GroEL expressed in Escherichia coli DH5alpha cells and Escherichia coli GroES expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of denatured pig heart MDH refolding by measuring reduction in NADH production incubated for 60 mins by micro plate reader analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
GroEL/ES inhibitors as potential antibiotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.36 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3115911 | — | — | 1 | 6.16 |
| CHEMBL3115913 | — | — | 1 | 6.10 |
| CHEMBL3115912 | — | — | 1 | 6.03 |
| CHEMBL3115914 | — | — | 1 | 5.92 |
| CHEMBL1632145 | — | — | 1 | 5.85 |
| CHEMBL3115927 | — | — | 1 | 5.58 |
| CHEMBL3112623 | — | — | 1 | 5.57 |
| CHEMBL1713063 | — | — | 1 | 5.52 |
| CHEMBL3115924 | — | — | 1 | 5.44 |
| CHEMBL1557710 | — | — | 1 | 5.33 |
| CHEMBL3115926 | — | — | 1 | 5.33 |
| CHEMBL3115920 | — | — | 1 | 5.32 |
| CHEMBL3115921 | — | — | 1 | 5.27 |
| CHEMBL3115919 | — | — | 1 | 5.24 |
| CHEMBL1411862 | — | — | 1 | 5.19 |
| CHEMBL3115908 | — | — | 1 | 5.12 |
| CHEMBL3115928 | — | — | 1 | 4.62 |
| CHEMBL3116088 | — | — | 1 | 4.62 |
| CHEMBL3115929 | — | — | 1 | 4.51 |
| CHEMBL3116086 | — | — | 1 | 4.38 |
| CHEMBL3116087 | — | — | 1 | - |
| CHEMBL3116089 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3115911 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3115913 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3115912 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL3115914 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1632145 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3115927 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3112623 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1713063 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3115924 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1557710 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3115926 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3115920 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3115921 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3115919 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1411862 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3115908 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3115928 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3116088 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3115929 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3116086 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL3116087 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3116089 | — | IC50 | > | 100000.0 | nM | - |