Assay Detail
Functional
CHEMBL3813348
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Antiproliferative activity against human NCI-H1975 cells over expressing EGFR after 48 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Facile and efficient synthesis and biological evaluation of 4-anilinoquinazoline derivatives as EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.51 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3809954 | — | — | 1 | 6.96 |
| CHEMBL3808905 | — | — | 1 | 6.44 |
| CHEMBL3809681 | — | — | 1 | 6.32 |
| CHEMBL3810044 | — | — | 1 | 6.17 |
| CHEMBL3810237 | — | — | 1 | 6.06 |
| CHEMBL3808709 | — | — | 1 | 5.94 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.91 |
| CHEMBL3808904 | — | — | 1 | 5.73 |
| CHEMBL3809390 | — | — | 1 | 5.52 |
| CHEMBL1688539 | — | — | 1 | 5.35 |
| CHEMBL3808628 | — | — | 1 | 5.15 |
| CHEMBL92985 | — | — | 1 | 5.12 |
| CHEMBL329672 | — | — | 1 | 4.98 |
| CHEMBL290096 | — | — | 1 | 4.98 |
| CHEMBL3808479 | — | — | 1 | 4.97 |
| CHEMBL1622791 | — | — | 1 | 4.63 |
| CHEMBL117697 | — | — | 1 | 4.50 |
| CHEMBL289959 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3809954 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3808905 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3809681 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3810044 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL3810237 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3808709 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL939 | GEFITINIB | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL3808904 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL3809390 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL1688539 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL3808628 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL92985 | — | IC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL329672 | — | IC50 | = | 10380.0 | nM | 4.98 |
| CHEMBL290096 | — | IC50 | = | 10560.0 | nM | 4.98 |
| CHEMBL3808479 | — | IC50 | = | 10640.0 | nM | 4.97 |
| CHEMBL1622791 | — | IC50 | = | 23510.0 | nM | 4.63 |
| CHEMBL117697 | — | IC50 | = | 31320.0 | nM | 4.50 |
| CHEMBL289959 | — | IC50 | = | 35620.0 | nM | 4.45 |