Assay Detail
Functional
CHEMBL3813352
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Antiproliferative activity against human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.01 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285063 | — | — | 1 | 5.71 |
| CHEMBL3809045 | — | — | 1 | 5.69 |
| CHEMBL52765 | — | — | 1 | 4.95 |
| CHEMBL3810326 | — | — | 1 | 4.84 |
| CHEMBL48802 | SULFORAPHANE | 3.0 | 1 | 4.80 |
| CHEMBL3809481 | — | — | 1 | 4.79 |
| CHEMBL3808664 | — | — | 1 | 4.79 |
| CHEMBL3808661 | — | — | 1 | 4.77 |
| CHEMBL3810177 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285063 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL3809045 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL52765 | — | IC50 | = | 11140.0 | nM | 4.95 |
| CHEMBL3810326 | — | IC50 | = | 14380.0 | nM | 4.84 |
| CHEMBL48802 | SULFORAPHANE | IC50 | = | 15760.0 | nM | 4.80 |
| CHEMBL3809481 | — | IC50 | = | 16280.0 | nM | 4.79 |
| CHEMBL3808664 | — | IC50 | = | 16080.0 | nM | 4.79 |
| CHEMBL3808661 | — | IC50 | = | 17060.0 | nM | 4.77 |
| CHEMBL3810177 | — | IC50 | = | 17060.0 | nM | 4.77 |