Assay Detail
Functional
CHEMBL3815295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream forms after 72 hrs by Alamar blue assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.16 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.41 |
| CHEMBL3814328 | — | — | 1 | 6.96 |
| CHEMBL3814914 | — | — | 1 | 6.92 |
| CHEMBL3814549 | — | — | 1 | 6.82 |
| CHEMBL3815012 | — | — | 1 | 6.80 |
| CHEMBL3813814 | — | — | 1 | 6.57 |
| CHEMBL3813761 | — | — | 1 | 6.34 |
| CHEMBL3814468 | — | — | 1 | 6.32 |
| CHEMBL3814637 | — | — | 1 | 6.27 |
| CHEMBL3814373 | — | — | 1 | 5.91 |
| CHEMBL3813987 | — | — | 1 | 5.84 |
| CHEMBL3814817 | — | — | 1 | 5.83 |
| CHEMBL3814553 | — | — | 1 | 5.83 |
| CHEMBL3814274 | — | — | 1 | 5.82 |
| CHEMBL3814114 | — | — | 1 | 5.80 |
| CHEMBL3814792 | — | — | 1 | 5.75 |
| CHEMBL3814194 | — | — | 1 | 5.67 |
| CHEMBL3814403 | — | — | 1 | 5.62 |
| CHEMBL3814996 | — | — | 1 | 5.58 |
| CHEMBL3813828 | — | — | 1 | 5.28 |
| CHEMBL3814558 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3814328 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3814914 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3814549 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3815012 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3813814 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3813761 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3814468 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3814637 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3814373 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL3813987 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL3814817 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL3814553 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL3814274 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL3814114 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL3814792 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL3814194 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL3814403 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3814996 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL3813828 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL3814558 | — | IC50 | = | 9470.0 | nM | 5.02 |