Assay Detail
Binding
CHEMBL3815405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human EGFR expressed in baculovirus by fluorescence based assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.76 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 9.29 |
| CHEMBL3814257 | — | — | 1 | 9.18 |
| CHEMBL3814882 | — | — | 1 | 9.11 |
| CHEMBL3814959 | — | — | 1 | 9.10 |
| CHEMBL3814211 | — | — | 1 | 9.07 |
| CHEMBL2031296 | — | — | 1 | 9.00 |
| CHEMBL3814956 | — | — | 1 | 8.97 |
| CHEMBL3814320 | — | — | 1 | 8.85 |
| CHEMBL3814812 | — | — | 1 | 8.82 |
| CHEMBL3815163 | — | — | 1 | 8.74 |
| CHEMBL3815074 | — | — | 1 | 8.69 |
| CHEMBL3633928 | — | — | 1 | 8.69 |
| CHEMBL3814447 | — | — | 1 | 8.65 |
| CHEMBL3814445 | — | — | 1 | 8.65 |
| CHEMBL3813728 | — | — | 1 | 8.65 |
| CHEMBL3815161 | — | — | 1 | 8.54 |
| CHEMBL3814694 | — | — | 1 | 8.43 |
| CHEMBL3814846 | — | — | 1 | 8.40 |
| CHEMBL3814816 | — | — | 1 | 8.30 |
| CHEMBL3814182 | — | — | 1 | 8.04 |
| CHEMBL3814460 | — | — | 1 | - |
| CHEMBL3815115 | — | — | 1 | - |
| CHEMBL3813876 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | IC50 | = | 0.509 | nM | 9.29 |
| CHEMBL3814257 | — | IC50 | = | 0.662 | nM | 9.18 |
| CHEMBL3814882 | — | IC50 | = | 0.772 | nM | 9.11 |
| CHEMBL3814959 | — | IC50 | = | 0.803 | nM | 9.10 |
| CHEMBL3814211 | — | IC50 | = | 0.854 | nM | 9.07 |
| CHEMBL2031296 | — | IC50 | = | 1.01 | nM | 9.00 |
| CHEMBL3814956 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL3814320 | — | IC50 | = | 1.43 | nM | 8.85 |
| CHEMBL3814812 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3815163 | — | IC50 | = | 1.81 | nM | 8.74 |
| CHEMBL3815074 | — | IC50 | = | 2.04 | nM | 8.69 |
| CHEMBL3633928 | — | IC50 | = | 2.03 | nM | 8.69 |
| CHEMBL3814447 | — | IC50 | = | 2.22 | nM | 8.65 |
| CHEMBL3814445 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL3813728 | — | IC50 | = | 2.26 | nM | 8.65 |
| CHEMBL3815161 | — | IC50 | = | 2.92 | nM | 8.54 |
| CHEMBL3814694 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3814846 | — | IC50 | = | 3.96 | nM | 8.40 |
| CHEMBL3814816 | — | IC50 | = | 5.06 | nM | 8.30 |
| CHEMBL3814182 | — | IC50 | = | 9.05 | nM | 8.04 |
| CHEMBL3814460 | — | IC50 | - | — | - | |
| CHEMBL3815115 | — | IC50 | - | — | - | |
| CHEMBL3813876 | — | IC50 | < | 0.495 | nM | - |