Assay Detail
Binding
CHEMBL3815441
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Inhibition of wild type EGFR (unknown origin) expressed in mouse BaF/3 cells assessed as cell growth inhibition after 72 hrs by MTS assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.80 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3814882 | — | — | 1 | 7.68 |
| CHEMBL3815074 | — | — | 1 | 7.41 |
| CHEMBL2031296 | — | — | 1 | 7.39 |
| CHEMBL3814956 | — | — | 1 | 7.21 |
| CHEMBL3814816 | — | — | 1 | 7.18 |
| CHEMBL3815163 | — | — | 1 | 7.12 |
| CHEMBL3814694 | — | — | 1 | 7.10 |
| CHEMBL3815161 | — | — | 1 | 7.06 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.90 |
| CHEMBL3814445 | — | — | 1 | 6.82 |
| CHEMBL3633928 | — | — | 1 | 6.73 |
| CHEMBL3814447 | — | — | 1 | 6.71 |
| CHEMBL3815115 | — | — | 1 | 6.61 |
| CHEMBL3814460 | — | — | 1 | 6.59 |
| CHEMBL3814257 | — | — | 1 | 6.58 |
| CHEMBL3814320 | — | — | 1 | 6.57 |
| CHEMBL3814812 | — | — | 1 | 6.57 |
| CHEMBL3814959 | — | — | 1 | 6.56 |
| CHEMBL3814940 | — | — | 1 | 6.53 |
| CHEMBL3814211 | — | — | 1 | 6.50 |
| CHEMBL3813728 | — | — | 1 | 6.48 |
| CHEMBL3813876 | — | — | 1 | 6.41 |
| CHEMBL3814846 | — | — | 1 | 6.39 |
| CHEMBL3814182 | — | — | 1 | 6.11 |
| CHEMBL3814021 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3814882 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3815074 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2031296 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3814956 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3814816 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3815163 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3814694 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3815161 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL939 | GEFITINIB | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL3814445 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3633928 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL3814447 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL3815115 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL3814460 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL3814257 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL3814320 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL3814812 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL3814959 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL3814940 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL3814211 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL3813728 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL3813876 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3814846 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3814182 | — | IC50 | = | 772.0 | nM | 6.11 |
| CHEMBL3814021 | — | IC50 | > | 500.0 | nM | - |