Assay Detail
Functional
CHEMBL3815447
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Antiproliferative activity against gefitinib-sensitive human PC9 cells assessed as cell viability after 72 hrs by cell titer-glo luminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.25 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.20 |
| CHEMBL3814257 | — | — | 1 | 6.65 |
| CHEMBL3814846 | — | — | 1 | 6.18 |
| CHEMBL3814211 | — | — | 1 | 6.02 |
| CHEMBL3814021 | — | — | 1 | 5.80 |
| CHEMBL3814940 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3814257 | — | IC50 | = | 224.7 | nM | 6.65 |
| CHEMBL3814846 | — | IC50 | = | 661.6 | nM | 6.18 |
| CHEMBL3814211 | — | IC50 | = | 961.1 | nM | 6.02 |
| CHEMBL3814021 | — | IC50 | = | 1583.0 | nM | 5.80 |
| CHEMBL3814940 | — | IC50 | = | 2156.0 | nM | 5.67 |