Assay Detail

CHEMBL3815583

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cytotoxicity against human HCT116 cells

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HCT-116
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

Esvan YJ, Giraud F, Pereira E, Suchaud V, Nauton L, Théry V, Dezhenkova LG, Kaluzhny DN, Mazov VN, Shtil AA, Anizon F, Moreau P.
Bioorg Med Chem (2016) 24 : 3116 -3124
PubMed 27255178 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.76	5.76

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL16958	STAUROSPORINONE	—	1	5.76

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL16958	STAUROSPORINONE	IC50	=	1720.0	nM	5.76