Assay Detail
ADMET
CHEMBL3815854
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assay
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pEC50 | 13 | - | - |
| EC50 | 4 | 7.62 | 8.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL778 | DEXMEDETOMIDINE | 4.0 | 1 | 8.67 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 7.52 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 7.52 |
| CHEMBL289480 | RILMENIDINE | 4.0 | 1 | 6.75 |
| CHEMBL3814593 | — | — | 1 | - |
| CHEMBL3814220 | — | — | 1 | - |
| CHEMBL3814521 | — | — | 1 | - |
| CHEMBL3814626 | — | — | 1 | - |
| CHEMBL3814276 | — | — | 1 | - |
| CHEMBL3814259 | — | — | 1 | - |
| CHEMBL3813724 | — | — | 1 | - |
| CHEMBL3814535 | — | — | 1 | - |
| CHEMBL3593723 | — | — | 1 | - |
| CHEMBL3593725 | — | — | 1 | - |
| CHEMBL57895 | EFAROXAN | 2.0 | 1 | - |
| CHEMBL353972 | ATIPAMEZOLE | 2.0 | 1 | - |
| CHEMBL3815157 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL778 | DEXMEDETOMIDINE | EC50 | = | 2.138 | nM | 8.67 |
| CHEMBL134 | CLONIDINE | EC50 | = | 30.2 | nM | 7.52 |
| CHEMBL679 | EPINEPHRINE | EC50 | = | 30.2 | nM | 7.52 |
| CHEMBL289480 | RILMENIDINE | EC50 | = | 177.83 | nM | 6.75 |
| CHEMBL3814593 | — | pEC50 | - | — | - | |
| CHEMBL3814220 | — | pEC50 | - | — | - | |
| CHEMBL3814521 | — | pEC50 | - | — | - | |
| CHEMBL3814626 | — | pEC50 | - | — | - | |
| CHEMBL3814276 | — | pEC50 | - | — | - | |
| CHEMBL3814259 | — | pEC50 | - | — | - | |
| CHEMBL3813724 | — | pEC50 | - | — | - | |
| CHEMBL3814535 | — | pEC50 | - | — | - | |
| CHEMBL3593723 | — | pEC50 | - | — | - | |
| CHEMBL3593725 | — | pEC50 | - | — | - | |
| CHEMBL57895 | EFAROXAN | pEC50 | - | — | - | |
| CHEMBL353972 | ATIPAMEZOLE | pEC50 | - | — | - | |
| CHEMBL3815157 | — | pEC50 | - | — | - |