Assay Detail
Functional
CHEMBL3816028
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Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.02 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3813907 | — | — | 1 | 6.66 |
| CHEMBL2153000 | — | — | 1 | 6.64 |
| CHEMBL3814977 | — | — | 1 | 6.37 |
| CHEMBL2153005 | — | — | 1 | 6.21 |
| CHEMBL3813854 | — | — | 1 | 6.07 |
| CHEMBL3815039 | — | — | 1 | 6.01 |
| CHEMBL2153012 | — | — | 1 | 5.91 |
| CHEMBL3814169 | — | — | 1 | 5.74 |
| CHEMBL2153004 | — | — | 1 | 5.61 |
| CHEMBL2153002 | — | — | 1 | 5.51 |
| CHEMBL2153011 | — | — | 1 | 5.49 |
| CHEMBL3814122 | — | — | 1 | - |
| CHEMBL2153001 | — | — | 1 | - |
| CHEMBL3814033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3813907 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2153000 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3814977 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2153005 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3813854 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3815039 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2153012 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL3814169 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL2153004 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL2153002 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL2153011 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL3814122 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2153001 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3814033 | — | IC50 | > | 5000.0 | nM | - |