Assay Detail
Functional
CHEMBL3816033
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Antiproliferative activity against mouse BA/F3 cells expressing TPR-Met after 72 hrs by CCK8 assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.70 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 8.04 |
| CHEMBL2103868 | CABOZANTINIB S-MALATE | 4.0 | 1 | 7.70 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 7.66 |
| CHEMBL3815128 | — | — | 1 | 7.05 |
| CHEMBL3813791 | — | — | 1 | 6.96 |
| CHEMBL3814828 | — | — | 1 | 6.92 |
| CHEMBL3814773 | — | — | 1 | 6.80 |
| CHEMBL3815081 | — | — | 1 | 6.79 |
| CHEMBL3814321 | — | — | 1 | 6.78 |
| CHEMBL3814710 | — | — | 1 | 6.73 |
| CHEMBL3814311 | — | — | 1 | 6.71 |
| CHEMBL3813954 | — | — | 1 | 6.70 |
| CHEMBL3814741 | — | — | 1 | 6.67 |
| CHEMBL3814470 | — | — | 1 | 6.61 |
| CHEMBL3814295 | — | — | 1 | 6.59 |
| CHEMBL3814456 | — | — | 1 | 6.49 |
| CHEMBL3814205 | — | — | 1 | 6.40 |
| CHEMBL3814870 | — | — | 1 | 6.28 |
| CHEMBL3813891 | — | — | 1 | 6.25 |
| CHEMBL3815159 | — | — | 1 | 6.21 |
| CHEMBL3814459 | — | — | 1 | 6.20 |
| CHEMBL3814072 | — | — | 1 | 6.13 |
| CHEMBL3813953 | — | — | 1 | 6.12 |
| CHEMBL3815094 | — | — | 1 | 6.06 |
| CHEMBL3813717 | — | — | 1 | - |
| CHEMBL3814918 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL2103868 | CABOZANTINIB S-MALATE | IC50 | = | 19.86 | nM | 7.70 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 21.9 | nM | 7.66 |
| CHEMBL3815128 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3813791 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3814828 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL3814773 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL3815081 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL3814321 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL3814710 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL3814311 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL3813954 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3814741 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL3814470 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL3814295 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL3814456 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL3814205 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL3814870 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL3813891 | — | IC50 | = | 566.0 | nM | 6.25 |
| CHEMBL3815159 | — | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL3814459 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL3814072 | — | IC50 | = | 745.0 | nM | 6.13 |
| CHEMBL3813953 | — | IC50 | = | 765.0 | nM | 6.12 |
| CHEMBL3815094 | — | IC50 | = | 879.0 | nM | 6.06 |
| CHEMBL3813717 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3814918 | — | IC50 | > | 1000.0 | nM | - |