Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3816044

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
ChEMBL ↗
108
Total Activities
36
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type HEK293-A
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Putative P2Y purinoceptor 10 (CHEMBL3562168) ↗
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity.
Jung S, Inoue A, Nakamura S, Kishi T, Uwamizu A, Sayama M, Ikubo M, Otani Y, Kano K, Makide K, Aoki J, Ohwada T.
J Med Chem (2016) 59 : 3750 -3776
PubMed 27077565 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 69 6.96 8.18
Emax 36 - -
pEC50 3 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3814492 — — 3 8.18
CHEMBL3813843 — — 3 7.77
CHEMBL1742484 — — 3 7.61
CHEMBL3813751 — — 3 7.38
CHEMBL3815090 — — 3 7.35
CHEMBL4299634 — — 3 6.54
CHEMBL3814147 — — 3 6.49
CHEMBL4299669 — — 3 6.35
CHEMBL4299658 — — 3 6.35
CHEMBL3814763 — — 3 6.33
CHEMBL3814009 — — 3 6.22
CHEMBL3813950 — — 3 -
CHEMBL3814525 — — 3 -
CHEMBL3815069 — — 3 -
CHEMBL3815141 — — 3 -
CHEMBL3814818 — — 3 -
CHEMBL3813767 — — 3 -
CHEMBL3814440 — — 3 -
CHEMBL3814124 — — 3 -
CHEMBL3814356 — — 3 -
CHEMBL3814527 — — 3 -
CHEMBL3814437 — — 3 -
CHEMBL4299652 — — 3 -
CHEMBL3814235 — — 3 -
CHEMBL3814095 — — 3 -
CHEMBL4299627 — — 3 -
CHEMBL3814707 — — 3 -
CHEMBL3813812 — — 3 -
CHEMBL4299628 — — 3 -
CHEMBL3814643 — — 3 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3814492 — EC50 = 6.607 nM 8.18
CHEMBL3814492 — EC50 = 6.7 nM 8.17
CHEMBL3813843 — EC50 = 17.0 nM 7.77
CHEMBL3813843 — EC50 = 16.98 nM 7.77
CHEMBL1742484 — EC50 = 24.55 nM 7.61
CHEMBL1742484 — EC50 = 25.0 nM 7.60
CHEMBL3813751 — EC50 = 41.69 nM 7.38
CHEMBL3813751 — EC50 = 42.0 nM 7.38
CHEMBL3815090 — EC50 = 44.67 nM 7.35
CHEMBL3815090 — EC50 = 45.0 nM 7.35
CHEMBL4299634 — EC50 = 290.0 nM 6.54
CHEMBL4299634 — EC50 = 288.4 nM 6.54
CHEMBL3814147 — EC50 = 323.59 nM 6.49
CHEMBL3814147 — EC50 = 330.0 nM 6.48
CHEMBL4299658 — EC50 = 450.0 nM 6.35
CHEMBL4299669 — EC50 = 450.0 nM 6.35
CHEMBL4299669 — EC50 = 457.09 nM 6.34
CHEMBL4299658 — EC50 = 457.09 nM 6.34
CHEMBL3814763 — EC50 = 470.0 nM 6.33
CHEMBL3814763 — EC50 = 467.74 nM 6.33
CHEMBL3814009 — EC50 = 602.56 nM 6.22
CHEMBL3814009 — EC50 = 610.0 nM 6.21
CHEMBL3814809 — Emax - — -
CHEMBL3813825 — Emax - — -
CHEMBL4299690 — Emax - — -
CHEMBL4299628 — Emax - — -
CHEMBL3813751 — Emax = 12.4 % -
CHEMBL3814235 — Emax - — -
CHEMBL3814095 — Emax - — -
CHEMBL4299627 — Emax - — -
CHEMBL3814707 — Emax - — -
CHEMBL3813812 — Emax - — -
CHEMBL3814492 — Emax = 10.8 % -
CHEMBL1742484 — Emax = 12.5 % -
CHEMBL3814437 — Emax - — -
CHEMBL4299652 — Emax - — -
CHEMBL4299634 — Emax = 7.2 % -
CHEMBL3814124 — Emax - — -
CHEMBL3814092 — Emax - — -
CHEMBL3814763 — Emax = 10.6 % -
CHEMBL4299633 — Emax < 3.0 % -
CHEMBL3813773 — Emax - — -
CHEMBL3814009 — Emax = 7.5 % -
CHEMBL4299658 — Emax = 3.9 % -
CHEMBL3814437 — EC50 < 1000.0 nM -
CHEMBL3814643 — EC50 < 1000.0 nM -
CHEMBL4299628 — EC50 < 1000.0 nM -
CHEMBL3813812 — EC50 < 1000.0 nM -
CHEMBL3814527 — EC50 < 1000.0 nM -
CHEMBL3814707 — EC50 < 1000.0 nM -