Assay Detail
Binding
CHEMBL3817039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression after 24 hrs by RT-PCR analysis
3
Total Activities
1
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 8.22 | 8.22 |
| Efficacy | 1 | - | - |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3814206 | — | — | 3 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3814206 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3814206 | — | Efficacy | = | 91.0 | % | - |
| CHEMBL3814206 | — | Activity | - | — | - |