Assay Detail
Binding
CHEMBL3819955
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currents
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Cell Type | AZT |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium channel subfamily K member 2 (CHEMBL1075183) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.84 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1491 | AMLODIPINE | 4.0 | 1 | 6.37 |
| CHEMBL1275655 | — | — | 1 | 6.12 |
| CHEMBL15848 | ANANDAMIDE | — | 1 | 6.00 |
| CHEMBL30008 | FLUNARIZINE | 2.0 | 1 | 5.60 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1491 | AMLODIPINE | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1275655 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL15848 | ANANDAMIDE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL30008 | FLUNARIZINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 8200.0 | nM | 5.09 |