Assay Detail
Binding
CHEMBL3819964
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Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate addition
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.02 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189620 | — | — | 1 | 9.02 |
| CHEMBL3817958 | — | — | 1 | 9.00 |
| CHEMBL3818013 | — | — | 1 | 8.00 |
| CHEMBL2159748 | — | — | 1 | 7.64 |
| CHEMBL3818020 | — | — | 1 | 7.49 |
| CHEMBL3819136 | — | — | 1 | 7.34 |
| CHEMBL3819096 | — | — | 1 | 6.00 |
| CHEMBL3818815 | — | — | 1 | 5.82 |
| CHEMBL3818902 | — | — | 1 | 5.68 |
| CHEMBL3819346 | — | — | 1 | 5.40 |
| CHEMBL3819362 | — | — | 1 | 5.12 |
| CHEMBL3819408 | — | — | 1 | 4.92 |
| CHEMBL3818446 | — | — | 1 | 4.21 |
| CHEMBL3818472 | — | — | 1 | 4.20 |
| CHEMBL3819072 | — | — | 1 | 4.19 |
| CHEMBL3818541 | — | — | 1 | 4.17 |
| CHEMBL3818999 | — | — | 1 | 4.10 |
| CHEMBL3818703 | — | — | 1 | - |
| CHEMBL3819297 | — | — | 1 | - |
| CHEMBL3819233 | — | — | 1 | - |
| CHEMBL3818697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189620 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL3817958 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3818013 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2159748 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3818020 | — | Ki | = | 32.5 | nM | 7.49 |
| CHEMBL3819136 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL3819096 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL3818815 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3818902 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL3819346 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL3819362 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL3819408 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL3818446 | — | Ki | = | 62000.0 | nM | 4.21 |
| CHEMBL3818472 | — | Ki | = | 62500.0 | nM | 4.20 |
| CHEMBL3819072 | — | Ki | = | 65000.0 | nM | 4.19 |
| CHEMBL3818541 | — | Ki | = | 67000.0 | nM | 4.17 |
| CHEMBL3818999 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL3818703 | — | Ki | > | 150000.0 | nM | - |
| CHEMBL3819297 | — | Ki | > | 150000.0 | nM | - |
| CHEMBL3819233 | — | Ki | > | 150000.0 | nM | - |
| CHEMBL3818697 | — | Ki | > | 150000.0 | nM | - |