Assay Detail
Binding
CHEMBL3819983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged LSD1 (2 to 852 residues) (unknown origin) using H3K4me2 substrate assessed as reduction in H2O2 production by fluorescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.29 | 4.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2426136 | NAMOLINE | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2426136 | NAMOLINE | IC50 | = | 51000.0 | nM | 4.29 |