Compound Detail
CHEMBL2426136
NAMOLINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL2426136 |
| Name | NAMOLINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DYEGRZKBJMKSKD-UHFFFAOYSA-N |
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
293.6
MW (Da)
3.37
ALogP
4
HBA
0
HBD
73.3
PSA (Ų)
0.60
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 4.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysine-specific histone demethylase 1A CHEMBL6136 | IC50 | 4.29 | 4.29 | 51000.0 | 5 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysine-specific histone demethylase 1A | IC50 | = | 51000.0 | nM | 4.29 | Inhibition of GST-tagged recombinant LSD1 (2 to 852) (unknown origin) using H3K4... | 24237195 |
| Lysine-specific histone demethylase 1A | IC50 | = | 51000.0 | nM | 4.29 | Inhibition of GST-tagged LSD1 (2 to 852 residues) (unknown origin) using H3K4me2... | 27046190 |
| Lysine-specific histone demethylase 1A | IC50 | = | 51000.0 | nM | 4.29 | Inhibition of LSD1 (unknown origin) | 29247860 |
| Lysine-specific histone demethylase 1A | IC50 | = | 51000.0 | nM | 4.29 | Inhibition of GST-tagged human LSD1 (2 to 852 residues) expressed in baculovirus... | 33619958 |
| Lysine-specific histone demethylase 1A | IC50 | = | 51000.0 | nM | 4.29 | Inhibition of LSD1 (unknown origin) | 38214982 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24007511 | 10.1021/jm400792m | Lysine-specific histone demethylase 1A | 1 |
| 24237195 | 10.1021/jm400870h | Lysine-specific histone demethylase 1A | 1 |
| 27046190 | 10.1021/acs.jmedchem.6b00078 | Lysine-specific histone demethylase 1A | 1 |
| 29247860 | 10.1016/j.ejmech.2017.12.001 | Lysine-specific histone demethylase 1A | 1 |
| 33619958 | 10.1021/acs.jmedchem.0c02176 | Lysine-specific histone demethylase 1A | 1 |
| 38214982 | 10.1021/acs.jmedchem.3c02133 | Lysine-specific histone demethylase 1A | 1 |
Data from ChEMBL 36 via Core Engine