Assay Detail
Binding
CHEMBL4253684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LSD1 (unknown origin)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.44 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3104250 | — | — | 1 | 7.89 |
| CHEMBL3926080 | — | — | 1 | 7.75 |
| CHEMBL4289507 | — | — | 1 | 7.70 |
| CHEMBL3651585 | — | — | 1 | 7.16 |
| CHEMBL4291413 | — | — | 1 | 7.05 |
| CHEMBL4284293 | — | — | 1 | 7.05 |
| CHEMBL4290752 | — | — | 1 | 7.01 |
| CHEMBL3415352 | — | — | 1 | 6.19 |
| CHEMBL3621615 | — | — | 1 | 5.92 |
| CHEMBL3775735 | — | — | 1 | 5.77 |
| CHEMBL1797705 | — | — | 1 | 5.72 |
| CHEMBL4285048 | — | — | 1 | 5.43 |
| CHEMBL257990 | (+)-TRANYLCYPROMINE | — | 1 | 5.20 |
| CHEMBL2426136 | NAMOLINE | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3104250 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3926080 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4289507 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3651585 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4291413 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4284293 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4290752 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3415352 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3621615 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3775735 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1797705 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4285048 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL257990 | (+)-TRANYLCYPROMINE | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL2426136 | NAMOLINE | IC50 | = | 51000.0 | nM | 4.29 |