Assay Detail
Binding
CHEMBL5540464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LSD1 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Combination Therapy and Dual-Target Inhibitors Based on LSD1: New Emerging Tools in Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.92 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5029010 | — | — | 1 | 8.40 |
| CHEMBL3104250 | — | — | 1 | 7.89 |
| CHEMBL4301645 | — | — | 1 | 7.80 |
| CHEMBL3781751 | IADADEMSTAT | 2.0 | 1 | 7.75 |
| CHEMBL3786182 | GSK2879552 | 1.0 | 1 | 7.62 |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | 4.68 |
| CHEMBL2426136 | NAMOLINE | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5029010 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3104250 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4301645 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3781751 | IADADEMSTAT | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3786182 | GSK2879552 | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL2426136 | NAMOLINE | IC50 | = | 51000.0 | nM | 4.29 |