Assay Detail
ADMET
CHEMBL3820118
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Induction of membrane damage in Mycobacterium bovis BCG incubated for 60 mins under dark condition using DiOC2 probe by fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.52 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224214 | CARBONYL CYANIDE M-CHLOROPHENYLHYDRAZONE | — | 1 | 5.52 |
| CHEMBL3818001 | — | — | 1 | - |
| CHEMBL3819568 | — | — | 1 | - |
| CHEMBL3819336 | — | — | 1 | - |
| CHEMBL3819419 | — | — | 1 | - |
| CHEMBL3817907 | — | — | 1 | - |
| CHEMBL3818181 | — | — | 1 | - |
| CHEMBL3818461 | — | — | 1 | - |
| CHEMBL376488 | BEDAQUILINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224214 | CARBONYL CYANIDE M-CHLOROPHENYLHYDRAZONE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3818001 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3819568 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3819336 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3819419 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3817907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3818181 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3818461 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL376488 | BEDAQUILINE | IC50 | > | 100000.0 | nM | - |