Assay Detail
Binding
CHEMBL3820451
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (CHEMBL3217379) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain K12) |
Publication
Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 49 | 5.10 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818894 | — | — | 1 | 6.16 |
| CHEMBL3819161 | — | — | 1 | 6.02 |
| CHEMBL3818561 | — | — | 1 | 6.01 |
| CHEMBL3818521 | — | — | 1 | 5.85 |
| CHEMBL3819246 | — | — | 1 | 5.77 |
| CHEMBL3818783 | — | — | 1 | 5.77 |
| CHEMBL3817872 | — | — | 1 | 5.75 |
| CHEMBL3818467 | — | — | 1 | 5.75 |
| CHEMBL3818609 | — | — | 1 | 5.70 |
| CHEMBL3818002 | — | — | 1 | 5.67 |
| CHEMBL3818008 | — | — | 1 | 5.66 |
| CHEMBL3818011 | — | — | 1 | 5.60 |
| CHEMBL3819387 | — | — | 1 | 5.58 |
| CHEMBL3819281 | — | — | 1 | 5.57 |
| CHEMBL3819223 | — | — | 1 | 5.46 |
| CHEMBL3819104 | — | — | 1 | 5.41 |
| CHEMBL276808 | — | — | 1 | 5.37 |
| CHEMBL3819092 | — | — | 1 | 5.28 |
| CHEMBL3818636 | — | — | 1 | 5.28 |
| CHEMBL3818368 | — | — | 1 | 5.24 |
| CHEMBL3818912 | — | — | 1 | 5.24 |
| CHEMBL3819267 | — | — | 1 | 5.24 |
| CHEMBL3818941 | — | — | 1 | 5.21 |
| CHEMBL3818195 | — | — | 1 | 5.16 |
| CHEMBL3818754 | — | — | 1 | 5.15 |
| CHEMBL3819638 | — | — | 1 | 5.07 |
| CHEMBL3819017 | — | — | 1 | 5.00 |
| CHEMBL3817885 | — | — | 1 | 4.97 |
| CHEMBL3818245 | — | — | 1 | 4.90 |
| CHEMBL3819098 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818894 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL3819161 | — | Kd | = | 950.0 | nM | 6.02 |
| CHEMBL3818561 | — | Kd | = | 965.0 | nM | 6.01 |
| CHEMBL3818521 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL3819246 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL3818783 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL3817872 | — | Kd | = | 1760.0 | nM | 5.75 |
| CHEMBL3818467 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL3818609 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL3818002 | — | Kd | = | 2130.0 | nM | 5.67 |
| CHEMBL3818008 | — | Kd | = | 2200.0 | nM | 5.66 |
| CHEMBL3818011 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL3819387 | — | Kd | = | 2600.0 | nM | 5.58 |
| CHEMBL3819281 | — | Kd | = | 2700.0 | nM | 5.57 |
| CHEMBL3819223 | — | Kd | = | 3500.0 | nM | 5.46 |
| CHEMBL3819104 | — | Kd | = | 3900.0 | nM | 5.41 |
| CHEMBL276808 | — | Kd | = | 4300.0 | nM | 5.37 |
| CHEMBL3819092 | — | Kd | = | 5300.0 | nM | 5.28 |
| CHEMBL3818636 | — | Kd | = | 5200.0 | nM | 5.28 |
| CHEMBL3818368 | — | Kd | = | 5700.0 | nM | 5.24 |
| CHEMBL3818912 | — | Kd | = | 5700.0 | nM | 5.24 |
| CHEMBL3819267 | — | Kd | = | 5800.0 | nM | 5.24 |
| CHEMBL3818941 | — | Kd | = | 6100.0 | nM | 5.21 |
| CHEMBL3818195 | — | Kd | = | 6900.0 | nM | 5.16 |
| CHEMBL3818754 | — | Kd | = | 7100.0 | nM | 5.15 |
| CHEMBL3819638 | — | Kd | = | 8500.0 | nM | 5.07 |
| CHEMBL3819017 | — | Kd | = | 10100.0 | nM | 5.00 |
| CHEMBL3817885 | — | Kd | = | 10700.0 | nM | 4.97 |
| CHEMBL3818245 | — | Kd | = | 12600.0 | nM | 4.90 |
| CHEMBL3819098 | — | Kd | = | 16300.0 | nM | 4.79 |
| CHEMBL3818695 | — | Kd | = | 23000.0 | nM | 4.64 |
| CHEMBL3818168 | — | Kd | = | 23300.0 | nM | 4.63 |
| CHEMBL3818498 | — | Kd | = | 26000.0 | nM | 4.58 |
| CHEMBL3818603 | — | Kd | = | 38000.0 | nM | 4.42 |
| CHEMBL3819615 | — | Kd | = | 50000.0 | nM | 4.30 |
| CHEMBL3818814 | — | Kd | = | 53000.0 | nM | 4.28 |
| CHEMBL3818744 | — | Kd | = | 52000.0 | nM | 4.28 |
| CHEMBL3818099 | — | Kd | = | 59400.0 | nM | 4.23 |
| CHEMBL3819390 | — | Kd | = | 68000.0 | nM | 4.17 |
| CHEMBL3818772 | — | Kd | = | 74200.0 | nM | 4.13 |
| CHEMBL3819144 | — | Kd | = | 82000.0 | nM | 4.09 |
| CHEMBL3818353 | — | Kd | = | 89200.0 | nM | 4.05 |
| CHEMBL3819351 | — | Kd | = | 97000.0 | nM | 4.01 |
| CHEMBL3818653 | — | Kd | - | — | - | |
| CHEMBL3817986 | — | Kd | - | — | - | |
| CHEMBL3818003 | — | Kd | - | — | - | |
| CHEMBL3819275 | — | Kd | = | 120000.0 | nM | - |
| CHEMBL3818302 | — | Kd | - | — | - | |
| CHEMBL178006 | — | Kd | = | 160000.0 | nM | - |