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Assay Detail

CHEMBL3820733

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 by NBT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Pyrimidine-based antimalarials: design strategies and antiplasmodial effects
Singh K, Kaur T
Medchemcomm (2016) 7 : 749 -768
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 8.22 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3818006 1 8.22
CHEMBL3819258 1 8.22
CHEMBL3819149 1 8.22
CHEMBL3819560 1 8.22
CHEMBL3819589 1 8.22
CHEMBL3819241 1 8.22
CHEMBL3819435 1 8.22
CHEMBL3817973 1 8.22
CHEMBL3818954 1 8.22
CHEMBL3819162 1 8.22
CHEMBL3818952 1 8.22
CHEMBL3817993 1 8.22
CHEMBL3818842 1 8.22
CHEMBL3819572 1 8.22
CHEMBL3116030 1 8.22
CHEMBL3818684 1 8.22
CHEMBL3819493 1 8.22
CHEMBL3819026 1 8.22
CHEMBL3819043 1 8.22
CHEMBL3818538 1 8.22
CHEMBL3819321 1 8.22
CHEMBL3116042 1 8.22
CHEMBL3819379 1 8.22
CHEMBL3819008 1 8.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3818006 IC50 = 6.0 nM 8.22
CHEMBL3819258 IC50 = 6.0 nM 8.22
CHEMBL3819149 IC50 = 6.0 nM 8.22
CHEMBL3819560 IC50 = 6.0 nM 8.22
CHEMBL3819589 IC50 = 6.0 nM 8.22
CHEMBL3819241 IC50 = 6.0 nM 8.22
CHEMBL3819435 IC50 = 6.0 nM 8.22
CHEMBL3817973 IC50 = 6.0 nM 8.22
CHEMBL3818954 IC50 = 6.0 nM 8.22
CHEMBL3819162 IC50 = 6.0 nM 8.22
CHEMBL3818952 IC50 = 6.0 nM 8.22
CHEMBL3817993 IC50 = 6.0 nM 8.22
CHEMBL3818842 IC50 = 6.0 nM 8.22
CHEMBL3819572 IC50 = 6.0 nM 8.22
CHEMBL3116030 IC50 = 6.0 nM 8.22
CHEMBL3818684 IC50 = 6.0 nM 8.22
CHEMBL3819493 IC50 = 6.0 nM 8.22
CHEMBL3819026 IC50 = 6.0 nM 8.22
CHEMBL3819043 IC50 = 6.0 nM 8.22
CHEMBL3818538 IC50 = 6.0 nM 8.22
CHEMBL3819321 IC50 = 6.0 nM 8.22
CHEMBL3116042 IC50 = 6.0 nM 8.22
CHEMBL3819379 IC50 = 6.0 nM 8.22
CHEMBL3819008 IC50 = 6.0 nM 8.22