Assay Detail
Functional
CHEMBL3820776
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Antiviral activity against oseltamivir-resistant Influenza A virus A/WSN/1933(H1N1) infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by CellTiter 96 AQueous Non-Radioactive cell proliferation assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.50 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | 4.0 | 1 | 8.82 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.26 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.79 |
| CHEMBL3819487 | — | — | 1 | 7.73 |
| CHEMBL3819314 | — | — | 1 | 7.73 |
| CHEMBL3819617 | — | — | 1 | 7.72 |
| CHEMBL3818553 | — | — | 1 | 7.37 |
| CHEMBL3818436 | — | — | 1 | 7.30 |
| CHEMBL3819450 | — | — | 1 | 7.18 |
| CHEMBL3818211 | — | — | 1 | 7.05 |
| CHEMBL3819492 | — | — | 1 | 6.58 |
| CHEMBL3817914 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 16.3 | nM | 7.79 |
| CHEMBL3819487 | — | EC50 | = | 18.6 | nM | 7.73 |
| CHEMBL3819314 | — | EC50 | = | 18.5 | nM | 7.73 |
| CHEMBL3819617 | — | EC50 | = | 19.1 | nM | 7.72 |
| CHEMBL3818553 | — | EC50 | = | 43.2 | nM | 7.37 |
| CHEMBL3818436 | — | EC50 | = | 50.3 | nM | 7.30 |
| CHEMBL3819450 | — | EC50 | = | 66.5 | nM | 7.18 |
| CHEMBL3818211 | — | EC50 | = | 88.7 | nM | 7.05 |
| CHEMBL3819492 | — | EC50 | = | 260.3 | nM | 6.58 |
| CHEMBL3817914 | — | EC50 | = | 343.2 | nM | 6.46 |