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Assay Detail

CHEMBL3821422

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125]I-CCK-8 from CCK-A receptor in rat pancreatic membrane after 2 hrs by gamma counting
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholecystokinin receptor type A (CHEMBL2871)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Cholecystokinin-1 receptor antagonists: 5-hydroxy-5-aryl-pyrrol-2-ones as anticancer agents
Lattmann E, Russell ST, Schwalbe CH, Shortt A, Balaram PN, Theochari E, Alharbi M, Narayanan R, Lattmann P
Medchemcomm (2016) 7 : 1138 -1145
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.34 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3818718 1 8.10
CHEMBL3818164 1 7.92
CHEMBL3818215 1 7.70
CHEMBL3819315 1 6.92
CHEMBL1255589 LORGLUMIDE SODIUM 1 6.77
CHEMBL3818578 1 6.70
CHEMBL3819054 1 6.52
CHEMBL3818781 1 6.44
CHEMBL3818410 1 6.10
CHEMBL3818822 1 5.70
CHEMBL3817873 1 5.60
CHEMBL3818165 1 5.60
CHEMBL3817870 1 5.44
CHEMBL3818705 1 5.40
CHEMBL3818303 1 5.35
CHEMBL3818437 1 5.12
CHEMBL3819216 1 -
CHEMBL3818877 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3818718 IC50 = 8.0 nM 8.10
CHEMBL3818164 IC50 = 12.0 nM 7.92
CHEMBL3818215 IC50 = 20.0 nM 7.70
CHEMBL3819315 IC50 = 120.0 nM 6.92
CHEMBL1255589 LORGLUMIDE SODIUM IC50 = 170.0 nM 6.77
CHEMBL3818578 IC50 = 200.0 nM 6.70
CHEMBL3819054 IC50 = 300.0 nM 6.52
CHEMBL3818781 IC50 = 360.0 nM 6.44
CHEMBL3818410 IC50 = 800.0 nM 6.10
CHEMBL3818822 IC50 = 2000.0 nM 5.70
CHEMBL3817873 IC50 = 2500.0 nM 5.60
CHEMBL3818165 IC50 = 2500.0 nM 5.60
CHEMBL3817870 IC50 = 3600.0 nM 5.44
CHEMBL3818705 IC50 = 4000.0 nM 5.40
CHEMBL3818303 IC50 = 4500.0 nM 5.35
CHEMBL3818437 IC50 = 7500.0 nM 5.12
CHEMBL3819216 IC50 > 10000.0 nM -
CHEMBL3818877 IC50 > 10000.0 nM -