Assay Detail
Functional
CHEMBL3821424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human AGS cells assessed as reduction in cell viability after 3 days by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AGS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cholecystokinin-1 receptor antagonists: 5-hydroxy-5-aryl-pyrrol-2-ones as anticancer agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.64 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818410 | — | — | 1 | 7.28 |
| CHEMBL3818164 | — | — | 1 | 6.65 |
| CHEMBL3818718 | — | — | 1 | 6.62 |
| CHEMBL3818215 | — | — | 1 | 6.58 |
| CHEMBL1255589 | LORGLUMIDE SODIUM | — | 1 | 6.54 |
| CHEMBL9387 | L-365260 | — | 1 | 6.17 |
| CHEMBL39263 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818410 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3818164 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL3818718 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL3818215 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL1255589 | LORGLUMIDE SODIUM | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL9387 | L-365260 | IC50 | = | 675.0 | nM | 6.17 |
| CHEMBL39263 | — | IC50 | > | 5000.0 | nM | - |