Assay Detail
Functional
CHEMBL3821524
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Negative inotropic activity in potassium depolarized guinea pig left atrium assessed as reduction in developed tension after 30 mins
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Left cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 6.49 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818643 | — | — | 1 | 7.66 |
| CHEMBL3819168 | — | — | 1 | 7.42 |
| CHEMBL3818880 | — | — | 1 | 7.19 |
| CHEMBL3819349 | — | — | 1 | 7.02 |
| CHEMBL3817941 | — | — | 1 | 7.00 |
| CHEMBL3819606 | — | — | 1 | 6.85 |
| CHEMBL3819180 | — | — | 1 | 6.85 |
| CHEMBL3819226 | — | — | 1 | 6.68 |
| CHEMBL3819185 | — | — | 1 | 6.66 |
| CHEMBL326076 | — | — | 1 | 6.64 |
| CHEMBL3818560 | — | — | 1 | 6.64 |
| CHEMBL3818275 | — | — | 1 | 6.55 |
| CHEMBL3817893 | — | — | 1 | 6.50 |
| CHEMBL3817895 | — | — | 1 | 6.41 |
| CHEMBL3819645 | — | — | 1 | 6.39 |
| CHEMBL3818473 | — | — | 1 | 6.37 |
| CHEMBL3818043 | — | — | 1 | 6.32 |
| CHEMBL116310 | — | — | 1 | 6.31 |
| CHEMBL115919 | — | — | 1 | 6.28 |
| CHEMBL3817892 | — | — | 1 | 6.19 |
| CHEMBL3819433 | — | — | 1 | 6.18 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 6.10 |
| CHEMBL3818844 | — | — | 1 | 6.06 |
| CHEMBL3819023 | — | — | 1 | 6.03 |
| CHEMBL3817876 | — | — | 1 | 5.92 |
| CHEMBL3818651 | — | — | 1 | 5.89 |
| CHEMBL419405 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818643 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3819168 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3818880 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3819349 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3817941 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3819606 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3819180 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3819226 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3819185 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL326076 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3818560 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3818275 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3817893 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3817895 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3819645 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3818473 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3818043 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL116310 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL115919 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3817892 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3819433 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL23 | DILTIAZEM | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3818844 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3819023 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL3817876 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3818651 | — | EC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL419405 | — | EC50 | = | 6580.0 | nM | 5.18 |