Assay Detail
Binding
CHEMBL3821775
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human serum butyrylcholinesterase preincubated for 5 mins followed by addition of S-butyrylthiocholine iodide as substrate measured after 60 to 120 mins by Ellmans method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of donepezilferulic acid hybrids as multi-target-directed ligands against Alzheimer's disease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.82 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3819383 | — | — | 1 | 6.61 |
| CHEMBL3818250 | — | — | 1 | 6.54 |
| CHEMBL3819083 | — | — | 1 | 6.17 |
| CHEMBL3819320 | — | — | 1 | 6.11 |
| CHEMBL3817981 | — | — | 1 | 6.00 |
| CHEMBL3818089 | — | — | 1 | 5.95 |
| CHEMBL3819231 | — | — | 1 | 5.91 |
| CHEMBL3819548 | — | — | 1 | 5.85 |
| CHEMBL3818512 | — | — | 1 | 5.84 |
| CHEMBL3818990 | — | — | 1 | 5.68 |
| CHEMBL3818689 | — | — | 1 | 5.59 |
| CHEMBL3818086 | — | — | 1 | 5.49 |
| CHEMBL3818782 | — | — | 1 | 5.37 |
| CHEMBL3818332 | — | — | 1 | 5.12 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.08 |
| CHEMBL3818992 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3819383 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL3818250 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL3819083 | — | IC50 | = | 669.0 | nM | 6.17 |
| CHEMBL3819320 | — | IC50 | = | 784.0 | nM | 6.11 |
| CHEMBL3817981 | — | IC50 | = | 988.0 | nM | 6.00 |
| CHEMBL3818089 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3819231 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL3819548 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL3818512 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL3818990 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL3818689 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL3818086 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL3818782 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL3818332 | — | IC50 | = | 7510.0 | nM | 5.12 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 8280.0 | nM | 5.08 |
| CHEMBL3818992 | — | IC50 | = | 145100.0 | nM | - |