Assay Detail
Binding
CHEMBL3821858
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Jack bean urease assessed as production of ammonia after 30 mins by indophenol method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxic and urease inhibitory activities of some novel isatin-derived bis-Schiff bases and their copper(ii) complexes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.88 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818469 | — | — | 1 | 7.40 |
| CHEMBL3818010 | — | — | 1 | 6.96 |
| CHEMBL3818885 | — | — | 1 | 6.47 |
| CHEMBL3818201 | — | — | 1 | 5.94 |
| CHEMBL3819266 | — | — | 1 | 5.78 |
| CHEMBL3818166 | — | — | 1 | 5.23 |
| CHEMBL260876 | THIOUREA | — | 1 | 4.65 |
| CHEMBL3818613 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818469 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3818010 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3818885 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3818201 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL3819266 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL3818166 | — | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL260876 | THIOUREA | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL3818613 | — | IC50 | = | 25200.0 | nM | 4.60 |