Assay Detail
Functional
CHEMBL3821992
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Cytotoxicity against Wnt-activated human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.50 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3819506 | — | — | 1 | 4.58 |
| CHEMBL3819020 | — | — | 1 | 4.41 |
| CHEMBL3818707 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3819506 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3819020 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL3818707 | — | IC50 | = | 120000.0 | nM | - |