Assay Detail
Binding
CHEMBL3822141
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Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 30 mins by Ellman's microplate assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural cholinesterase inhibitors from Myristica cinnamomea King.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.58 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.10 |
| CHEMBL1254269 | MALABARICONE A | — | 1 | 5.88 |
| CHEMBL489354 | MALABARICONE B | — | 1 | 5.74 |
| CHEMBL524100 | MALABARICONE C | — | 1 | 5.71 |
| CHEMBL3819036 | — | — | 1 | 5.19 |
| CHEMBL3818374 | — | — | 1 | 4.90 |
| CHEMBL3819024 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1254269 | MALABARICONE A | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL489354 | MALABARICONE B | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL524100 | MALABARICONE C | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL3819036 | — | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL3818374 | — | IC50 | = | 12660.0 | nM | 4.90 |
| CHEMBL3819024 | — | IC50 | = | 30670.0 | nM | 4.51 |