Assay Detail
Binding
CHEMBL3822340
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FITC-labeled Bak BH3 peptide binding to GST-tagged Bcl-XL (unknown origin) preincubated for 10 mins followed by FITC-labeled Bak BH3 peptide addition measured after 30 mins by fluorescence polarization assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecules targeting Mcl-1: the search for a silver bullet in cancer therapy
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 5.43 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551288 | APOGOSSYPOL | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551288 | APOGOSSYPOL | Ki | = | 3690.0 | nM | 5.43 |