Assay Detail
Binding
CHEMBL3824532
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human YES using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P] ATP
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.90 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3823861 | — | — | 1 | 7.92 |
| CHEMBL306380 | — | — | 1 | 7.44 |
| CHEMBL3823212 | — | — | 1 | 7.15 |
| CHEMBL3823849 | — | — | 1 | 6.46 |
| CHEMBL3799221 | — | — | 1 | 6.25 |
| CHEMBL3822591 | — | — | 1 | 6.16 |
| CHEMBL3824089 | — | — | 1 | - |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3823861 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL306380 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3823212 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3823849 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL3799221 | — | IC50 | = | 566.0 | nM | 6.25 |
| CHEMBL3822591 | — | IC50 | = | 696.0 | nM | 6.16 |
| CHEMBL3824089 | — | IC50 | < | 0.5 | nM | - |
| CHEMBL5416410 | DASATINIB | IC50 | < | 0.5 | nM | - |