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Assay Detail

CHEMBL3824752

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Functional
Potentiation of SNP-induced vasorelaxant activity in Sprague-Dawley rat endothelium-intact aortic rings assessed as SNP EC50 for reduction in L-phenylephrine hydrochloride-induced contraction by (Rvb = 7.98 +/- 0.02 No_unit)
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Aorta
Confidence 1 — Organism
Curated By Autocuration

Target

Aorta (CHEMBL613606)
Type TISSUE
Organism Rattus norvegicus

Publication

On the vasoprotective mechanisms underlying novel β-phosphorylated nitrones: Focus on free radical characterization, scavenging and NO-donation in a biological model of oxidative stress.
Cassien M, Petrocchi C, Thétiot-Laurent S, Robin M, Ricquebourg E, Kandouli C, Asteian A, Rockenbauer A, Mercier A, Culcasi M, Pietri S.
Eur J Med Chem (2016) 119 : 197 -217
PubMed 27162124 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 8.63 9.03
pEC50 6 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3823393 1 9.03
CHEMBL3823573 1 9.01
CHEMBL3823574 1 8.99
CHEMBL3824195 1 8.99
CHEMBL3823412 1 8.98
CHEMBL3823592 1 8.91
CHEMBL3823604 1 8.66
CHEMBL3824345 1 8.54
CHEMBL3823026 1 8.37
CHEMBL3823937 1 8.30
CHEMBL3824333 1 8.28
CHEMBL3822826 1 8.25
CHEMBL3823542 1 8.24
CHEMBL13210 1 8.22
CHEMBL3823032 1 -
CHEMBL3823459 1 -
CHEMBL288114 GALLIC ACID 2.0 1 -
CHEMBL145 CAFFEIC ACID 3.0 1 -
CHEMBL32749 FERULATE -1.0 1 -
CHEMBL109341 SINAPINATE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3823393 EC50 = 0.9333 nM 9.03
CHEMBL3823573 EC50 = 0.9772 nM 9.01
CHEMBL3823574 EC50 = 1.023 nM 8.99
CHEMBL3824195 EC50 = 1.023 nM 8.99
CHEMBL3823412 EC50 = 1.047 nM 8.98
CHEMBL3823592 EC50 = 1.23 nM 8.91
CHEMBL3823604 EC50 = 2.188 nM 8.66
CHEMBL3824345 EC50 = 2.884 nM 8.54
CHEMBL3823026 EC50 = 4.266 nM 8.37
CHEMBL3823937 EC50 = 5.012 nM 8.30
CHEMBL3824333 EC50 = 5.248 nM 8.28
CHEMBL3822826 EC50 = 5.623 nM 8.25
CHEMBL3823542 EC50 = 5.754 nM 8.24
CHEMBL13210 EC50 = 6.026 nM 8.22
CHEMBL3823032 pEC50 - -
CHEMBL3823459 pEC50 - -
CHEMBL288114 GALLIC ACID pEC50 - -
CHEMBL145 CAFFEIC ACID pEC50 - -
CHEMBL32749 FERULATE pEC50 - -
CHEMBL109341 SINAPINATE pEC50 - -