Assay Detail
Functional
CHEMBL3824754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasoprotective activity against oxidative stress-induced impairment of ACh-stimulated vasorelaxation in Sprague-Dawley rat endothelium-intact aortic rings assessed as reduction in L-phenylephrine hydrochloride-induced contraction preincubated for 10 to 20 mins in presence of xanthine-xanthine oxidase system prior to L-phenylephrine hydrochloride addition
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
On the vasoprotective mechanisms underlying novel β-phosphorylated nitrones: Focus on free radical characterization, scavenging and NO-donation in a biological model of oxidative stress.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.16 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3823412 | — | — | 1 | 7.55 |
| CHEMBL3823573 | — | — | 1 | 7.39 |
| CHEMBL3823574 | — | — | 1 | 7.27 |
| CHEMBL3823604 | — | — | 1 | 7.17 |
| CHEMBL3824345 | — | — | 1 | 6.83 |
| CHEMBL13210 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3823412 | — | EC50 | = | 28.18 | nM | 7.55 |
| CHEMBL3823573 | — | EC50 | = | 40.74 | nM | 7.39 |
| CHEMBL3823574 | — | EC50 | = | 53.7 | nM | 7.27 |
| CHEMBL3823604 | — | EC50 | = | 67.61 | nM | 7.17 |
| CHEMBL3824345 | — | EC50 | = | 147.91 | nM | 6.83 |
| CHEMBL13210 | — | EC50 | = | 173.78 | nM | 6.76 |