Assay Detail
Binding
CHEMBL3825518
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human N-terminal His-tagged cytoplasmic c-MET kinase domain (956 to 1390 residues) phosphorylation expressed in baculovirus expression system using Tyr peptide-6 substrate incubated for 1 hr in presence of ATP by Z-Lyte assay
48
Total Activities
47
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.31 | 6.00 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3822800 | — | — | 2 | 6.00 |
| CHEMBL3823418 | — | — | 1 | 5.96 |
| CHEMBL3823650 | — | — | 1 | 5.92 |
| CHEMBL3823321 | — | — | 1 | 5.92 |
| CHEMBL3823866 | — | — | 1 | 5.89 |
| CHEMBL3823193 | — | — | 1 | 5.68 |
| CHEMBL3823617 | — | — | 1 | 5.64 |
| CHEMBL3823701 | — | — | 1 | 5.50 |
| CHEMBL3822722 | — | — | 1 | 5.46 |
| CHEMBL3824070 | — | — | 1 | 5.28 |
| CHEMBL3823110 | — | — | 1 | 5.28 |
| CHEMBL3823086 | — | — | 1 | 5.28 |
| CHEMBL3822615 | — | — | 1 | 5.24 |
| CHEMBL3824255 | — | — | 1 | 5.24 |
| CHEMBL3823881 | — | — | 1 | 5.21 |
| CHEMBL3823395 | — | — | 1 | 5.16 |
| CHEMBL3822893 | — | — | 1 | 5.12 |
| CHEMBL3823553 | — | — | 1 | 5.11 |
| CHEMBL3822574 | — | — | 1 | 5.10 |
| CHEMBL3824063 | — | — | 1 | 5.09 |
| CHEMBL3822765 | — | — | 1 | 5.08 |
| CHEMBL3822560 | — | — | 1 | 5.07 |
| CHEMBL3823189 | — | — | 1 | 5.04 |
| CHEMBL3823377 | — | — | 1 | 4.94 |
| CHEMBL3823470 | — | — | 1 | 4.91 |
| CHEMBL481245 | — | — | 1 | 4.89 |
| CHEMBL2348314 | TYROSOL SINAPATE | — | 1 | 4.86 |
| CHEMBL3628211 | — | — | 1 | 4.70 |
| CHEMBL3822534 | — | — | 1 | - |
| CHEMBL3823265 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3822800 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3823418 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3823321 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3823650 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3823866 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3823193 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3823617 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3823701 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3822722 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3823110 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3824070 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3823086 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3822615 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3824255 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3823881 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3823395 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3822893 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3823553 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3822574 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3824063 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3822765 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3822560 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3823189 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3823377 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3823470 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL481245 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL2348314 | TYROSOL SINAPATE | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL3628211 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL3823683 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL53566 | TYROSOL | IC50 | > | 20000.0 | nM | - |
| CHEMBL3823869 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3823463 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3823770 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL226587 | TRANS-N-SINAPOYLTYRAMINE | IC50 | > | 20000.0 | nM | - |
| CHEMBL3823033 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3823074 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3823987 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3822697 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3822508 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3822598 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3823804 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3822690 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3822833 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3822800 | — | Inhibition | - | % | - | |
| CHEMBL3823265 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3822534 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3823769 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3823798 | — | IC50 | > | 20000.0 | nM | - |