Assay Detail
Binding
CHEMBL3825641
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38alpha (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.75 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237347 | GW559768X | — | 1 | 6.30 |
| CHEMBL3822938 | — | — | 1 | 5.97 |
| CHEMBL237345 | — | — | 1 | 5.43 |
| CHEMBL3823499 | — | — | 1 | 5.29 |
| CHEMBL3823809 | — | — | 1 | - |
| CHEMBL3822791 | — | — | 1 | - |
| CHEMBL3822754 | — | — | 1 | - |
| CHEMBL3822573 | — | — | 1 | - |
| CHEMBL3824056 | — | — | 1 | - |
| CHEMBL3823527 | — | — | 1 | - |
| CHEMBL3822577 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237347 | GW559768X | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3822938 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL237345 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL3823499 | — | IC50 | = | 5119.0 | nM | 5.29 |
| CHEMBL3823809 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3822791 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3822754 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3822573 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3824056 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3823527 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3822577 | — | IC50 | > | 5000.0 | nM | - |