Assay Detail
Functional
CHEMBL3825652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MDP-stimulated TNF-alpha release in human monocytes preincubated for 30 mins prior to MDP stimulation measured after 6 hrs by immunoassay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Monocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.10 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3823499 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3823499 | — | IC50 | = | 8.0 | nM | 8.10 |