Assay Detail
ADMET
CHEMBL3825880
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Inhibition of recombinant human CYP2B6 by P450-Glo luminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.90 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL833 | TICLOPIDINE | 4.0 | 1 | 6.22 |
| CHEMBL3822867 | — | — | 1 | 4.50 |
| CHEMBL3823873 | — | — | 1 | 4.45 |
| CHEMBL3822473 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL833 | TICLOPIDINE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3822867 | — | IC50 | = | 31760.0 | nM | 4.50 |
| CHEMBL3823873 | — | IC50 | = | 35670.0 | nM | 4.45 |
| CHEMBL3822473 | — | IC50 | = | 36160.0 | nM | 4.44 |