Assay Detail
Functional
CHEMBL3825939
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Potentiation of vincristine-induced cytotoxicity in Flp-In-293 cells assessed as vincristine IC50 at 10 uM after 72 hrs by SRB assay (Rvb = 5.9705 +/- 0.1791 nM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Flp-In-293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and bioevaluation of novel benzodipyranone derivatives as P-glycoprotein inhibitors for multidrug resistance reversal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.13 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3823024 | — | — | 1 | 9.18 |
| CHEMBL3822838 | — | — | 1 | 9.13 |
| CHEMBL3822907 | — | — | 1 | 9.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3823024 | — | IC50 | = | 0.6595 | nM | 9.18 |
| CHEMBL3822838 | — | IC50 | = | 0.7324 | nM | 9.13 |
| CHEMBL3822907 | — | IC50 | = | 0.8448 | nM | 9.07 |