Assay Detail
Functional
CHEMBL3825960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potentiation of vincristine-induced cytotoxicity in human HeLaS3 assessed as vincristine IC50 at 10 uM after 72 hrs by SRB assay (Rvb = 3.5543 +/- 0.2879 nM)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa S3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and bioevaluation of novel benzodipyranone derivatives as P-glycoprotein inhibitors for multidrug resistance reversal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.39 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3823024 | — | — | 1 | 9.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3823024 | — | IC50 | = | 0.4031 | nM | 9.39 |