Assay Detail
Functional
CHEMBL3829031
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by MTT assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.60 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827814 | — | — | 1 | 9.13 |
| CHEMBL3827517 | — | — | 1 | 8.70 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.47 |
| CHEMBL3827296 | — | — | 1 | 8.32 |
| CHEMBL3827650 | — | — | 1 | 8.24 |
| CHEMBL3827780 | — | — | 1 | 8.15 |
| CHEMBL3622533 | FIMEPINOSTAT | 2.0 | 1 | 8.13 |
| CHEMBL3827865 | — | — | 1 | 8.11 |
| CHEMBL3828628 | — | — | 1 | 8.04 |
| CHEMBL3828180 | — | — | 1 | 8.03 |
| CHEMBL3826997 | — | — | 1 | 7.99 |
| CHEMBL3828486 | — | — | 1 | 7.97 |
| CHEMBL3828492 | — | — | 1 | 7.88 |
| CHEMBL3828636 | — | — | 1 | 7.85 |
| CHEMBL3828518 | — | — | 1 | 7.83 |
| CHEMBL3827794 | — | — | 1 | 7.81 |
| CHEMBL3827281 | — | — | 1 | 7.79 |
| CHEMBL3827317 | — | — | 1 | 7.75 |
| CHEMBL3827612 | — | — | 1 | 7.56 |
| CHEMBL3827660 | — | — | 1 | 7.39 |
| CHEMBL3827004 | — | — | 1 | 7.33 |
| CHEMBL3828289 | — | — | 1 | 7.26 |
| CHEMBL3827489 | — | — | 1 | 7.24 |
| CHEMBL3828747 | — | — | 1 | 7.18 |
| CHEMBL3827398 | — | — | 1 | 7.12 |
| CHEMBL3827056 | — | — | 1 | 7.05 |
| CHEMBL3828070 | — | — | 1 | 6.80 |
| CHEMBL3827894 | — | — | 1 | 6.67 |
| CHEMBL3827738 | — | — | 1 | 6.62 |
| CHEMBL3828482 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827814 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL3827517 | — | IC50 | = | 1.99 | nM | 8.70 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 3.36 | nM | 8.47 |
| CHEMBL3827296 | — | IC50 | = | 4.73 | nM | 8.32 |
| CHEMBL3827650 | — | IC50 | = | 5.77 | nM | 8.24 |
| CHEMBL3827780 | — | IC50 | = | 7.05 | nM | 8.15 |
| CHEMBL3622533 | FIMEPINOSTAT | IC50 | = | 7.34 | nM | 8.13 |
| CHEMBL3827865 | — | IC50 | = | 7.85 | nM | 8.11 |
| CHEMBL3828628 | — | IC50 | = | 9.22 | nM | 8.04 |
| CHEMBL3828180 | — | IC50 | = | 9.25 | nM | 8.03 |
| CHEMBL3826997 | — | IC50 | = | 10.26 | nM | 7.99 |
| CHEMBL3828486 | — | IC50 | = | 10.63 | nM | 7.97 |
| CHEMBL3828492 | — | IC50 | = | 13.02 | nM | 7.88 |
| CHEMBL3828636 | — | IC50 | = | 13.99 | nM | 7.85 |
| CHEMBL3828518 | — | IC50 | = | 14.84 | nM | 7.83 |
| CHEMBL3827794 | — | IC50 | = | 15.38 | nM | 7.81 |
| CHEMBL3827281 | — | IC50 | = | 16.13 | nM | 7.79 |
| CHEMBL3827317 | — | IC50 | = | 17.95 | nM | 7.75 |
| CHEMBL3827612 | — | IC50 | = | 27.65 | nM | 7.56 |
| CHEMBL3827660 | — | IC50 | = | 40.24 | nM | 7.39 |
| CHEMBL3827004 | — | IC50 | = | 46.66 | nM | 7.33 |
| CHEMBL3828289 | — | IC50 | = | 54.35 | nM | 7.26 |
| CHEMBL3827489 | — | IC50 | = | 57.63 | nM | 7.24 |
| CHEMBL3828747 | — | IC50 | = | 66.55 | nM | 7.18 |
| CHEMBL3827398 | — | IC50 | = | 76.46 | nM | 7.12 |
| CHEMBL3827056 | — | IC50 | = | 89.32 | nM | 7.05 |
| CHEMBL3828070 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3827894 | — | IC50 | = | 214.2 | nM | 6.67 |
| CHEMBL3827738 | — | IC50 | = | 241.1 | nM | 6.62 |
| CHEMBL3828482 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL3828408 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1450.0 | nM | 5.84 |